CategorySwine Health - General Disease
Date Full Report Received11/06/2019
Date Abstract Report Received11/06/2019
InvestigationInstitution: Regents of the University of Minnesota
Primary Investigator: Dr. Fabio Augusto Vannucci Ph.D.
Funded ByNational Pork Board
Vesicular disease caused by Senecavirus A (SVA) has been an emerging concern on the swine industry due to its indistinguishable clinical presentation from high-consequence foreign animal diseases, including foot-and-mouth disease. The most common scenarios observed in SVA cases is the presence of vesicular lesions in finishing pigs and sows at or after arrival at packing plants from site with no previous history of the disease. The goal of the present research project was to understand the impact of transportation stress on early development of vesicular lesions, transmission and recurrence of clinical disease in persistently-infected sows.
The timeline for viremia and development of vesicular lesions were similar in stressed and non-stressed gilts. Virus transmission occurred to naïve-contact animals from infected animals 7 post-infection. These results were characterized by viremia (5 post-contact) and seroconversion (9 post-contact). Despite the lack of transmission observed after comingling infected-seeders and naïve animals at 21 and 35 post-infection of the seeders, gilts that have been recovered and cleared of the disease, resumed to shed the virus through feces and saliva 24 hours after stress (36 dpi). This result highlights the potential transmission of the virus under field conditions from asymptomatic animals that were previously assumed to be clear of the virus.
• Stress did not induce earlier viremia or appearance of vesicular disease infected pigs
• Infected-seeder pigs transmitted the virus to naïve animals when comingled 7 days post-infection
• Asymptomatic-carrier gilts that have recovered and cleared of the infection resumed shedding SVA in feces and saliva 24 hours after stress
• Reoccurrence of vesicular disease was not observed in asymptomatic-carrier gilts after stress