#06-074

Complete

Date Full Report Received

07/17/2009

Date Abstract Report Received

07/17/2009

Investigation

Institution:
Primary Investigator: ,

An opportunity was presented whereas sequential samples were collected in the midst of a natural outbreak of PMWS. This provided the basis to evaluate immunological and virological events in the midst of an outbreak. With this natural outbreak and the required samples we could test questions related to whether the cachexia in PMWS was due to the induction of inflammatory cytokines PCV virus load Results revealed an increase in TN-alpha across groups, an increase in PCV load across groups and a correlation of TNF and PCV virus load in a subset subjected to regression analyses. It should be noted that the cytokine levels and virus load were performed on banked samples, prohibiting additional sample collection.