Date Full Report Received05/19/2014
Date Abstract Report Received05/19/2014
InvestigationInstitution: The Ohio State University Research Foundation (OSURF)
Primary Investigator: Qiuhong Wang
Funded ByNational Pork Board
The highly contagious and deadly porcine epidemic diarrhea (PED) virus (PEDv) was first discovered in the US in April-May 2013. Since then the virus has spread rapidly nationwide causing high mortality among nursing piglets and significant economic losses. Currently there are no efficacious preventive measures or therapeutic tools to control PEDv: therefore, development of an effective PEDv vaccine for swine in the US should be a high priority. Since most viruses accumulate mutations and become attenuated (reduced pathogenicity or virulence) after serial passage in cell culture, the isolation of PEDv in cell culture is the first step toward the development of an attenuated vaccine, to study the basic biology of PEDv, and to develop in vitro PEDv immunoassays, inactivation assays and screen for PEDv antivirals. Our labs have started to work on PEDv since June, 2013. What we have achieved on PEDV research is listed below:
1. We have successfully propagated one US PEDv strain PC22A in Vero cells to high titers. The isolation of PEDv in cell culture is the first step toward the development of an attenuated vaccine.