Heterologous prime-boost vaccination protocols using whole inactivated influenza A virus vaccines to drive improved heterologous cross-protection
Effect of short term high tryptophan diet fed to sows on subsequent piglet behavior
Laws have been passed in several states requiring group housing for pregnant sows. However, the predominant problem with group housing sows is aggression. Different approaches, such as changing group size, space per sow, advanced technologies (such as electronic sow feeding),…
Live-animal assay for identifying correlates of cross-protection for swine influenza virus vaccines when vaccinated in the presence of maternal antibody.
Experimental live-attenuated influenza virus (LAIV) vaccines, delivered into the nose, have been shown protect pigs against influenza infection, more so than traditional inactivated commercial vaccines. In addition, LAIV vaccines have been shown to provide protection in piglets that have suckled…
Evaluating the effects of mitigation strategies on piglet welfare and future productivity after transport during different seasons
As consumer concern for swine welfare, husbandry methods, and antibiotic use in animal agriculture increase, so will the need for U.S. pork producers to demonstrate that current production practices not only increase animal performance, but also improve the overall health…
Use of interferon alpha as an immunomodulator and metaphylactic therapeutic during PRRSV outbreaks
The host response to virus infection begins almost immediately with recognition of virus by host cells leading to the production of antiviral substances such as interferons. One interferon, interferon alpha (IFNα), plays a significant role in the antiviral immune response…
PRRSV Identification by Virochip
Current identification and surveillance practices for PRRSV involves a few selected U.S. veterinary diagnostic laboratories performing quantitative RT-PCR and ORF5 nucleotide sequencing followed by restriction fragment length polymorphism, a process that typically takes two weeks or more. Therefore there is…
Comparison of porcine high fever disease isolates of PRRSV to US isolates for their ability to cause secondary bacterial infection in swine
The appearance of highly-pathogenic porcine reproductive and respiratory syndrome virus (PRRSV) isolates in Asia necessitates investigation into the clinical repercussions of these viruses if the strains were to appear in the US. Epidemiologic data from Asian outbreaks suggest that disease…
Haemophilus parasuis Proteomics for Vaccine Design
Gene expression in lymph nodes of PRRSV-infected pigs
The aim of this study was to acquire a better understanding of PRRS disease through a deeper knowledge of gene expression changes that occur in pulmonary lymph nodes during acute comparative porcine reproductive and respiratory syndrome virus (PRRSV), porcine circovirus…