As stated in the contract, we require an industry summary of the project, suitable for immediate public release by the Board. The purpose of the industry summary is to provide producers with a quick reference to research results supported by…
An Interferon-inducible Porcine Reproductive and Respiratory Syndrome Virus Isolate
The objective of this project was to determine the full length sequences of an interferon-inducible PRRSV strain A2MC2 and determine whether it can induce neutralizing antibodies. Type I interferons (IFNs), such as IFN-α and -β, are critical to antiviral innate…
Mechanism of PRRSV inhibition of interferon-mediated antiviral response
The objective of this project was to study the effect of PRRSV infection on interferon (IFN) signaling and determine the mechanism of the effect. Type I IFNs, such as IFN-α and -β, are critical to innate immunity against viruses and…
Development of a New Generation of Antisense Antiviral Drug against PRRSV
This project has explored a novel class of antiviral drugs to suppress PRRSV replication. These drugs were designed on the basis of PRRSV genomic sequences. Their specific binding to the virus genome is expected to interfere with virus replication. Such…