#08-050

Complete

Date Full Report Received

04/14/2010

Date Abstract Report Received

04/14/2010

Investigation

Institution:
Primary Investigator:

A vaccine was constructed using a gene from swine influenza and structural genes from alphavirus as the vaccine backbone.  This vaccine induced both immunity and strong protection when given to pigs with no antibodies to influenza derived by suckling.  Given the history of influenza viruses to change quickly, this vector system is well suited for influenza vaccine generation as one can rapidly produce vaccines with this method. However, if pigs did receive antibodies to influenza by suckling, the vaccine was unable to overcome the maternal antibodies and did not induce immunity and protection.  Possibly, producers could avoid maternal antibody interference by vaccinating sows and gilts with currently available vaccines and then giving pigs vaccines not yet developed and readily available that is based on flu proteins that are not affected by maternal antibody.