#15-139

Complete

Date Full Report Received

04/23/2018

Date Abstract Report Received

04/23/2018

Investigation

Institution:
Primary Investigator:

The objectives of this study were to identify previously unknown regions in the pig genome that act to regulate genes, and therefore play a role in the traits the pigs exhibit. Eight tissues from two adult male Yorkshire pigs were used for this study to profile a wide range of biological functions important to the industry. Biological assays were performed on these tissues to identify DNA-protein interactions that have been shown to be associated with promoters, enhancers, and insulators, which are important regulatory regions of the genome that exist outside of genes. A machine learning algorithm was used to integrate the data from these assays into predictions of regulatory elements for each tissue in the study. The results showed similarity with previous done in human and mouse, which supports the accuracy of the predictions. Identifying these regions will allow researchers to better understand the genetic basis for complex traits such as feed efficiency and disease resistance, which will in turn allow breeders to create new genetic lines of pigs to improve production efficiency, animal welfare, and food safety.

Key Findings:

  • Identify novel regulatory elements of genes that are potentially associated with economically important traits such as growth rate, feed efficiency and immune function.
  • Functions of regulatory elements annotated on the genes provide novel targets for genetic selection and breeding.
  • Assist in filtering SNPs on identification potential causative mutations associated with economically important traits.