As an alternative to counteract the increased feed costs, dried distillers grains with solubles (DDGS) have been increasingly included in pig diets. Much research has been conducted recently to evaluate growth performance and carcass characteristics associated with feeding DDGS to pigs. However, little is known about the potential effect of DDGS on the the susceptibility to infection or colonization with pathogens. Therefore, two experiments were conducted to determine if inclusion of DDGS in the diet of grow-finish pigs affects their susceptibility to or the intestinal levels and shedding of Salmonella. In experiment 1, 36 pigs (12 pigs/treatment) were assigned to 3 treatments: Control diet with no corn DDGS, diet with 20% corn DDGS, or diet with 40% corn DDGS. After an adaptation period of 2 weeks, each pig was inoculated with Salmonella and euthanized after 6 hours to determine their susceptibility to the challenge. In experiment 2, 40 pigs (20 pigs/treatment) were assigned to 2 treatments: Control diet with no corn DDGS or diet with 30% corn DDGS. After 2 weeks, each pig was inoculated with Salmonella; individual fecal samples were collected during 5 weeks, and pigs were euthanized at 3 and 5 weeks post-challenge to determine intestinal colonization. In experiment 1, no differences among treatments were observed on the susceptibility to Salmonella infection. In experiment 2, most pigs shed Salmonella at one of the fecal samplings during the study period, with control pigs having a higher cumulative shedding frequency than pigs receiving the diet with 30% DDGS. There was no difference between treatments regarding the average Salmonella fecal shedding level. Also, no difference between treatments was found on the frequency or levels of Salmonella in intestinal samples collected at 3 or 5 weeks post-challenge. In conclusion, dietary inclusion of corn DDGS does not alter the susceptibility to or colonization with Salmonella of grow-finishing pigs.