#08-268

Complete

Date Full Report Received

02/15/2010

Date Abstract Report Received

02/15/2010

The porcine circovirus of type 2 (PCV-2) is involved in porcine circovirus diseases such as post-weaning multisystemic wasting syndrome (PMWS), reproduction disorders, porcine dermatitis and nephropathy syndrome. All these disease cause a serious economic problem to the swine industry. PMWS outbreaks that occurred in 2005 in North America were assumed to be linked to the emergence of PCV-2 belonging to the PCV-2b genogroup. However, no clear evidence was found between this PCV-2b genogroup and a higher virulence. The objectives of the present work were to compare the virulence of a strain of PCV-2a genogroup to that of a strain of PCV-2b genogroup and to check if a specific signature of each genogroup located in the capsid protein, unique component of the external structure of the virus, could be a factor of virulence. The results showed that the PCV-2b strain was more virulent than the PCV-2a one and that modifications of the capsid motif attenuated the virulence. Altogether this findings put a new perspective on possible improvement when designing future PCV-2 vaccines.

Contact: Béatrice Grasland, Afssa LERAPP, Fr-22440 Ploufragan, France b.grasland@afssa.fr