CategorySwine Health - General Disease
Date Full Report Received02/15/2010
Date Abstract Report Received02/15/2010
InvestigationInstitution: Afssa), Agence Francaise de Securite Sanitaire des Aliments (French Food Safety Agency
Primary Investigator: Beatrice Grasland
Funded ByNational Pork Board
The porcine circovirus of type 2 (PCV-2) is involved in porcine circovirus diseases such as post-weaning multisystemic wasting syndrome (PMWS), reproduction disorders, porcine dermatitis and nephropathy syndrome. All these disease cause a serious economic problem to the swine industry. PMWS outbreaks that occurred in 2005 in North America were assumed to be linked to the emergence of PCV-2 belonging to the PCV-2b genogroup. However, no clear evidence was found between this PCV-2b genogroup and a higher virulence. The objectives of the present work were to compare the virulence of a strain of PCV-2a genogroup to that of a strain of PCV-2b genogroup and to check if a specific signature of each genogroup located in the capsid protein, unique component of the external structure of the virus, could be a factor of virulence. The results showed that the PCV-2b strain was more virulent than the PCV-2a one and that modifications of the capsid motif attenuated the virulence. Altogether this findings put a new perspective on possible improvement when designing future PCV-2 vaccines.
Contact: Béatrice Grasland, Afssa LERAPP, Fr-22440 Ploufragan, France firstname.lastname@example.org