#04-171

Complete

Date Full Report Received

08/30/2006

Date Abstract Report Received

08/30/2006

Investigation

Institution:
Primary Investigator:

Porcine reproductive and respiratory syndrome (PRRS) is the most devastating swine disease. This project strives to develop new and safer vaccine for the elimination of PRRSV from swine herds. Previous studies have shown the GP5 and M protein on the virus surface are immunogenic and are good candidates for developing subunit protein vaccines. Corn is the major feedstock for pigs, and it is an ideal host for vaccine development. For the reported period, we have demonstrated that recombinant GP5 can be successfully expressed in transgenic corn callus. The overall goal of this project is to develop transgenic corns expressing PRRSV immunogens as edible recombinant vaccines to help eliminate the PRRS virus from swine herds. The success of this project will have a significant impact on our combat against this devastating virus and the swine producers. Not only will new and safer vaccines be produced, but the vaccines will be much cheaper and extremely suitable for mass immunization. Swine producers will be directly benefited from purchasing cheaper and easy-to-be-administered vaccines and from the improved productivity of the swine farm.