Date Full Report Received08/30/2006
Date Abstract Report Received08/30/2006
InvestigationInstitution: Virginia Polytechnic Institute and State University
Primary Investigator: Chenming (Mike) Zhang
Funded ByNational Pork Board
Porcine reproductive and respiratory syndrome (PRRS) is the most devastating swine disease. This project strives to develop new and safer vaccine for the elimination of PRRSV from swine herds. Previous studies have shown the GP5 and M protein on the virus surface are immunogenic and are good candidates for developing subunit protein vaccines. Corn is the major feedstock for pigs, and it is an ideal host for vaccine development. For the reported period, we have demonstrated that recombinant GP5 can be successfully expressed in transgenic corn callus. The overall goal of this project is to develop transgenic corns expressing PRRSV immunogens as edible recombinant vaccines to help eliminate the PRRS virus from swine herds. The success of this project will have a significant impact on our combat against this devastating virus and the swine producers. Not only will new and safer vaccines be produced, but the vaccines will be much cheaper and extremely suitable for mass immunization. Swine producers will be directly benefited from purchasing cheaper and easy-to-be-administered vaccines and from the improved productivity of the swine farm.