#04-026

Complete

Date Full Report Received

08/22/2005

Date Abstract Report Received

12/20/2006

Investigation

Institution:
Primary Investigator:

In this investigation we attempted to establish that a topical vaccine delivery strategy pioneered in mice could be applied to intestinal tract infections of pigs, such as enterotoxigenic E. coli. Initial attempts to protect pigs from E. coli diarrhea largely failed and the level of immune response was disappointing. Subsequent investigations were conducted in an attempt to optimize the method of topical vaccine delivery. Thus far we have not been successful in obtaining a desirable immune response, but are continuing to explore methods to optimize this type of vaccine delivery. Alternative methods to the delivery of vaccines to address diseases of the intestinal, respiratory, or urogenital tract (diseases of mucosal epithelium) all have limitations. Consequently, vaccines to such diseases are largely unavailable. Results from studies by other investigators using a mouse model suggest that topical vaccine delivery has substantial potential. However, our discussions with the developers of the mouse model suggest that perfecting the vaccine delivery method will be no trivial task. We plan continued work in this area.