This project is designed to study a completely new approach to developing a new vaccine against PRRS for the pork industry. It is based on a new understanding of how the AIDS virus causes disease in humans and includes the application of a new vaccine technology called “Immune Refocusing”. The virus appears to act like a matador waving a red cape in front of the bull (the human or pig) to which the bull charges repeatedly and unsuccessfully. The grant was designed to see if a similar response existed in a PRRS infection to which we believe it does. Next to identify the location of the red cape on the PRRS virus, which was accomplished and last to make a new set of vaccines using he virus but removing and changing the color of the red cape to allow the bull, human, pig to see the virus and attack it instead of the decoy. These test vaccines have been made and ready for testing in animals.