Date Full Report Received


Date Abstract Report Received



Primary Investigator:

Porcine epidemic diarrhea virus unexpectedly entered the North American swine population in 2013 resulting in widespread and devastating disease. Understanding this virus and its infection characteristics has proven difficult worldwide. Experimental inoculation of three-week-old pigs with PEDV isolate US/Iowa/18984/2013 induced severe clinical disease with stalled weight gain for approximately 10 days post inoculation. Diarrhea with measurable differences in villous to crypt ratios were first observed on dpi 3; however, viral shedding and PEDV antigen detection within infected cells can be as early as 24 hrs post-infection leading to possible transmission of virus prior to the onset of clinical signs. Porcine epidemic diarrhea virus shedding, under the conditions of this wean-pig study, was much longer than previously reported as viral shedding was detected up to dpi 24 which was approximately two weeks post resolution of clinical disease. Accordingly, an absence of clinical diarrhea does not eliminate the risk of PEDV transmission in weaned pigs. In neonatal piglets PEDV infection was severe resulting in diarrhea, dehydration, and death. Viral shedding was confirmed by 12 hr post infection. Comparing neonate study results with previous reports, our data confirms that clinical differences can exist among PEDV isolates and PED can be as severe as TGE in neonates.