The focus of our research funded by the National Pork Board was to develop second generation killed PRRS vaccines. The portion of the PRRS virus responsible for stimulating the neutralizing immune response (an antibody response which removes the virus from…
Assesment Of Vertical Transmission From Parity One Sows Infected With A Low Dose And Mild Pathogenic Prrsv Isolate
In order to generate a protocol to sample lactating piglets to evaluate PRRSV chronically infected herds twelve PRRSV naïve pregnant sows were individually housed and assigned to three different groups. Sows in group A were injected with 3 mL of…
Rational Design of a New Generation of PRRSV Differential (Marker) Vaccines
We started this project with the conviction that the use of vaccines will always be a cost-efficient method and the preferred approach to control PRRSV infections , provided the efficacy and safety concerns of the current vaccines are contemplated and…
Proof-of-Concept -Anti-Idiotype Induces Anti-PRRSV Neutralizing Antibodies in Swine
PRRS is the most costly disease U.S. swine producers confront and little progress has been made in recent years to mprove the situation. In studying swine antibody responses, we discovered the presence of serum auto-anti-idiotypic antibodies in pigs experimentally infected…
Purified PRRS Viral Proteins
PRRS virus proteins that are immunogenic in pigs were expressed and purified. Nsp2p and nucleocapsid proteins are and will be available to PRRS researchers and can be used to detect exposure to PRRS virus, monitor immune responses, and to investigate…
Sampling of adult boars during early infection using a new serum collection technique for PRRS PCR testing prior to semen collection
In the study, serum had a higher quantity of virus than the blood swab samples as expected. The blood swab method can be done on boars each collection day, thus is user-friendly when compared with snaring and collection of blood…
Genetic Resistance to Porcine Reproductive Respiratory Syndrome Virus (PRRSV)
In the experiment pigs of two distinctly different populations were challenged with PRRS virus. The lines differed in physiological responses to virus (body temperature, weight gain, ability to replicate virus, and lung lesions), indicating that genetic variation exists. This suggests…