Transport is a risk factor for the spread of PRRSV between farms. To reduce this risk, several sanitation protocols have been scientifically validated. Based on these results, producers now have efficacious options for the sanitation of at-risk trailers. For further…
Interaction of PRRSV and Porcine Dendritic Cells: Potential Role in Viral Persistence
Porcine reproductive and respiratory syndrome virus (PRRSV) may persist in tissues of pigs for months. How the virus persists in certain pigs remains to be determined. It is possible that a subset of white blood cells trap the virus and…
Construction of Dynamic Aerosol Toroid Chambers
PRRSV costs the US swine industry 560 million dollars each year in lost productivity. We can now successfully eliminate PRRSV from individual farms, but we cannot keep herds from becoming re-infected. With the NPB-stated goal of national PRRSV elimination, an…
A pilot project to determine the feasibility of controlling PRRS within a selected region
The purpose of this project was to determine if pork producers within a defined region were willing to test their herds for PRRS virus, share the results with other cooperating producers, and share the results of their control methods. We…
Macrophage cell-lines for in vitro propagation of porcine reproductive and respiratory syndrome virus
Vaccination of pigs against PRRSV is the most prudent and logical way of controlling this economically important disease. Production of vaccines requires large scale propagation of PRRSV in the laboratories of pharmaceutical companies. The cell-line that is currently available for…
Development of a Killed Subunit PRRS Vaccine
The focus of our research funded by the National Pork Board was to develop second generation killed PRRS vaccines. The portion of the PRRS virus responsible for stimulating the neutralizing immune response (an antibody response which removes the virus from…
Assesment Of Vertical Transmission From Parity One Sows Infected With A Low Dose And Mild Pathogenic Prrsv Isolate
In order to generate a protocol to sample lactating piglets to evaluate PRRSV chronically infected herds twelve PRRSV naïve pregnant sows were individually housed and assigned to three different groups. Sows in group A were injected with 3 mL of…
Rational Design of a New Generation of PRRSV Differential (Marker) Vaccines
We started this project with the conviction that the use of vaccines will always be a cost-efficient method and the preferred approach to control PRRSV infections , provided the efficacy and safety concerns of the current vaccines are contemplated and…
Proof-of-Concept -Anti-Idiotype Induces Anti-PRRSV Neutralizing Antibodies in Swine
PRRS is the most costly disease U.S. swine producers confront and little progress has been made in recent years to mprove the situation. In studying swine antibody responses, we discovered the presence of serum auto-anti-idiotypic antibodies in pigs experimentally infected…
Purified PRRS Viral Proteins
PRRS virus proteins that are immunogenic in pigs were expressed and purified. Nsp2p and nucleocapsid proteins are and will be available to PRRS researchers and can be used to detect exposure to PRRS virus, monitor immune responses, and to investigate…