Implementation of a PRRSV Strain Database (Renewal)

A PRRSV ORF5 database, accessible worldwide, was improved for swine producers, practitioners and researchers (http://prrsv.ahc.umn.edu/). This database, established to fulfill one objective of the PRRS Initiative of the National Pork Board, consists of PRRSV ORF5 nucleotide sequence data generated by…

Development of a Broadly Protective PRRS Vaccine

The current vaccines against PRRSV protect pigs exposed to the strain used to make the vaccine, but not to the many field strains that herds encounter. The lack of protection against heterologous challenge may be caused by genetic variability of…

Physical Characterization of the PRRSV Virion

The research here shows that PRRSV grows in cells as a population of viruses with the same shape, the same RNA molecules, and the same protein composition. There was no evidence for multiple forms that varied in infectivity or in…

Mechanisms of Failed Protection Against PRRS in Sow Herds

We have established a set of standard protocols and reagents for whole genome PRRSV sequencing and assembly. Phylogenetic comparisons amongst 10 pairs of homologous strains confirmed several regions undergoing positive selection (changes in protein sequences assumed to be in reaction…