#15-020

Complete

Date Full Report Received

12/01/2016

Date Abstract Report Received

12/01/2016

Investigation

Institution:
Primary Investigator:
Co-Investigators: Ying Fang, Biao He

The goal of this project was to evaluate candidate influenza vaccines that induce broad immunity against multiple influenza viruses in pigs. These vaccines have been designed to induce immune responses against viruses within the influenza A virus H1N1 subtype, which includes multiple clusters that co-circulate in pigs. Using parainfluenza virus 5 (PIV5) as a vector, we now show that each of our two influenza virus hemagglutinins (HAs) can induce antibodies against multiple influenza viruses within the H1N1 subtype, and that both can protect pigs against infection with the A/swine/Alberta/25/2009-H1N1 influenza virus. These results show that both vaccines have the ability to induce broad immunity within the H1N1 subtype, with evidence of protection against one of these viruses in a direct vaccine:challenge. Vaccines designed in this manner can be used to minimize the number of HAs included in current influenza vaccines, while simultaneously increasing the breadth of immunity induced.